The United States has recently experienced numerous cases of human bird flu, all of which have been relatively mild. However, this changed when the Centers for Disease Control and Prevention confirmed that a patient in Louisiana had been hospitalized with a severe case of avian influenza caused by the H5N1 virus. This is the first instance of severe illness linked to the virus in the US. The virus has already caused significant damage to poultry and wild bird populations, as well as infecting over 800 dairy herds in 16 states. The virus has also been transmitted to humans who have come into contact with infected animals. Since April, there have been a total of 61 reported human cases of bird flu in eight states, with 37 cases linked to exposure to sick or infected dairy cows and 21 cases linked to exposure to poultry farms and culling operations. However, these cases only resulted in mild respiratory symptoms and conjunctivitis, and all patients have fully recovered. This severe case is significant because bird flu has been known to cause severe illness and even death in other countries, with a mortality rate of up to 50%. The Louisiana Department of Health and CDC have determined that the hospitalized patient had been exposed to sick and dead birds in backyard flocks, making this the first case in the US linked to a backyard flock rather than a commercial farm. While the investigation into the source of the infection is ongoing, it is believed that the patient had direct contact with sick or dead birds on their property. This is a concerning development, as previous cases in the US have been linked to exposure to commercial farms or sporadic human cases. The CDC is currently conducting further genomic sequencing of the virus to identify potential mutations and better understand its spread.